Virol . Iwao Kukimoto and Tadahito Kanda Promoter of Human Papillomavirus Type 16670 Transcription Factor hSkn - 1 a Activates the P Displacement of YY
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Genotype Distribution of Human Papillomaviruses in Japanese Women with Abnormal Cervical Cytology
We report the prevalence and genotype distribution of human papillomaviruses (HPVs) among Japanese women with abnormal cervical cytology using the PGMY-CHUV assay, one of PGMY-PCR-based lineblot assays that was validated and shown to be suitable for the detection of multiple HPV types in a specimen with minimum bias. Total DNA was extracted from cervical exfoliated cells collected from 326 outp...
متن کاملCCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters.
Expression of human papillomavirus genes increases as the target cell, the keratinocyte, differentiates. CCAAT displacement protein (CDP) is a cellular protein which has been shown in other cell types to negatively regulate gene expression in undifferentiated cells but not in differentiated cells. We have previously shown that a 66-bp purine-thymidine-rich sequence (the 66-mer) binds CDP and ne...
متن کاملA promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA.
Human papillomavirus type 16 (HPV-16) has the capacity to transform human primary keratinocytes. Maintenance of the transformed phenotype requires constitutive expression of the oncoproteins E6 and E7. The low-risk HPV types express E7 from monocistronic mRNA, but for the high-risk types, no mRNA that encodes E7 as the first open reading frame (ORF) has been identified. We recently identified a...
متن کاملConserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins.
Papillomavirus early gene expression is regulated by the virus gene-encoded E2 proteins. The best-characterized E2 protein, encoded by bovine papillomavirus type 1 (BPV-1), has been shown to interact with basal transcription factor IIB (TFIIB) and the TATA binding protein basal transcription factor (N. M. Rank and P. F. Lambert, J. Virol. 69:6323-6334, 1995). We demonstrate that the potent E2 t...
متن کاملApobec 3 Deaminases Induce Hypermutation な in Human Papillomavirus Type 16 Dna upon に Interferon - く Stimulation
ぬひ Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3 proteins are ねど interferon (IFN)-inducible antiviral factors counteracting various viruses such as ねな hepatitis B virus (HBV) and human immunodeficiency virus-1 (HIV-1) by inducing ねに cytidine (C)-to-uracil (U) mutations in viral DNA and inhibiting reverse transcription. ねぬ However, whether APOBEC3s can hypermutate human papillom...
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